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CRANAD 2

简要描述:

CRANAD 2 (1193447-34-5)is a near-infrared probe that binds to Aβ40 aggregates and elicits an emission blue shift. It was shown to bind to plaques in APP-PS1 transgenic mice, in vitro.

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Biochem/physiol Actions

CRANAD 2 is a near-infrared (NIR) Aβ plaque-specific fluorescent probe. CRANAD 2 penetrates the blood brain barrier and has a high affinity for Aβ aggregates with a Kd of 38 nM. Upon interacting with Aβ aggregates, exhibits a 70-fold increase in fluorescence intensity accompanied by a 90 nm blue shift from 805 to 715 nm and a large increase in quantum yield. has been used to detect Aβ deposits noninvasively in vivo in transgenic Tg2576 mice.

CAS:1193447-34-5

 

  • 中文名称:CRANAD-2

 

  • 英文名称:CRANAD-2

 

  • 英文别名:(T-4)-[(1E,6E)-1,7-bis[4-(dimethylamino)phenyl]-1,6-heptadiene-3,5-dionato-kO3,kO5]difluoro-boron

 

  • CAS号:1193447-34-5

 

  • 分子式:C23H25BF2N2O2

 

  • 分子量:410.26500

 

  • 精确质量:410.19800

 

  • PSA:32.78000

 

  • LogP:4.93870

  • 外观与性状:深蓝色或黑色粉末

 

  • 可溶性:DMSO: soluble 0.2 mg/mL, clear (warmed)

 

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